This course is designed to introduce graduate students to basic concepts and techniques in the study of protein structure and function. Course coverage will include structural determinants, relationship of structure to function, thermodynamics of protein interactions, protein/ligand interactions, kinetics, transition state theory, enzyme mechanisms and protein purification techniques.

Advanced study of the physiology, pharmacology, and pathophysiology of the cardiovascular system. Prerequisites: Consent of the instructor.

A quantitative treatment of the dynamics of drug absorption, distribution, metabolism, and excretion, including the development of mathematical models for these processes. Application of analog and digital computation will be discussed. Prerequisites: Mathematics 3001 or 4001, and/or Consent of Department Head.

An advanced treatment of factors affecting drug availability from dosage forms and the influence of the route of administration and the dosage regimen on drug availability. Prerequisite: 5013 or Consent of Department Head.

Students will be introduced to disease processes at the cellular level. The course will serve as an introduction to pathophysiology building on the anatomy and physiological courses that students have already completed. Prerequiste(s): First Year Standing. Credit or registration in PHRD 4020.

Coverage of microscopic anatomy of tissues, organs, and organ systems.

Cellular and molecular mechanisms of drug action. Prerequisites: 4013, 4014 or consent of Department Head.

Laboratory techniques used to evaluate drug action. Nine hours laboratory. Prerequisite: Credit or registration in 5021.

This course focuses on the biochemical and molecular biopharmaceutical bases of therapeutic intervention with medicinal substances, the actions of these substances (beneficial and harmful), and accordingly, the associated foundational concepts of molecular pharmacology and toxicology. Prerequistes: PHRD 4002 Principles of Drug Action I.

Orientation to current drug information systems, appropriate search strategies utilizing primary, secondary and tertiary resources combined with applications of common statistical tests seen in medical literature. Prerequisite: P1 Status.

The study of natural products used in medicine, pharmacy and allied fields. Emphasis is placed on isolation, purification and synthetic derivatives. One hour lecture and six hours laboratory. Prerequisite: Consent of Department Head.

The study of natural products used in medicine, pharmacy and allied fields. Emphasis is placed on isolation, purification and synthetic derivatives. One hour lecture and six hours laboratory. Prerequisite: 5034, consent of Department Head.

The student will continue to build on the knowledge from pathophysiology I as complete organ systems are introduced and the impact of diseases on these systems are studied. Prerequistes: PHRD 4012 and credit or registration in PHRD 4049.

A detailed coverage of biochemical mechanisms of toxicity. Prerequisite: Credit or registration in Toxicology 4012 or equivalent.

Current developments in pharmaceutical disciplines. Applicable to all disciplines. Attendance required for every graduate student each semester. Not more than 2 cr. applicable to the M.S. degree or an additional 4 cr. toward the Ph.D. degree, not to exceed 6 cr. for the Ph.D. degree.

Introduction and application of basic concepts of research methodology and design needed for efficient evaluation, utilization and clinical application of medication information available in medical literature. Prerequisites: PHRD 4033 and credit or registration in PHRD 4070.

An advanced course presenting the pathophysiology, clinical features, and pharmacology of cancers, as well as the latest advances and developments in cancer therapeutics. Prerequisites: Permission of the instructor.

Individualized investigations of selected problems in pharmaceutical chemistry, pharmacognosy, pharmacology, clinical pharmacy, and pharmacy administration. Prerequistes: Coordinator consent.

This course will provide students with basic concepts in pharmacogenetics and the role of inheritance on inter-individual variation in drug response. In addition, the class with provide students with an appreciation of how pharmacogenetic and pharmacogenomic fields impact pharmaceutical care. Prerequisites: PHAR 5013

Advanced analytical procedures; use of new techniques and equipment. Prerequisites: Credit or registration in 5068 and Consent of Department Head.

A laboratory course to accompany 5066. Six hours laboratory. Prerequisite: Credit or registration in 5066.

A study of traditional and contemporary approaches to drug design and development. Basic concepts important to receptor-ligand interactions will be introduced. Literature examples will be used to illustrate contemporary methods, such as molecular modeling, QSAR, and combinatorial strategies. Prerequisite: 4009 or Consent of Instructor.

An elective course to develop knowledge in the pharmaceutical sciences, how to use analytical techniques to characterize and evaluate drug delivery systems. Prerequisite: Graduate standing

Introduce students to the necessary physicochemical parameters, determination of kinetic rate profiles, characterization of physical properties, and compatibility with common excipients of new drug substances.

This fundamental course on pharmaceutical solids provides a comprehensive, cutting-edge overview of ideas, issues, language, and methodologies of pharmaceutical solid-state research.

Theoretical and practical aspects involved in the design of dosage forms including the development of drug molecules and industrial scale manufacturing.

Cellular mechanisms of adverse chemical effects in biological systems. Areas of emphasis include principles of pathology, genotoxicity, carcinogenicity, teratogenicity and toxic responses of major organ systems. Prerequisites: 4015, 4089.

Common laboratory techniques used to evaluate chemical toxicity. One hour lecture, six hours laboratory. Prerequisite: Credit or registration in 5081.

This course deals with the fundamentals of surface and interfacial phenomena encountered by pharmaceutical scientists in the development of dosage forms.

This course deals with the fundamentals aspects of chemical kinetics applied to the stability of pharmaceutical raw materials and final dosage forms.

4 credits each. Intended to provide the graduate student with hands-on laboratory experience in methods commonly used in A. Neurotoxicology, B. Aquatic Toxicology, C. Immunotoxicology, D. Hepatotoxicology. Prerequisites: For A, B, and D: PHAR 5050 and Consent of Instructor. For C: 4008 or PHAR 4023.

A survey of contemporary pharmacotherapeutic agents, emphasizing drug design elements as relates to mechanistic and clinical characteristics. Prerequisites: PHAR 5139 or permission of the instructor.

Molecular bases of therapeutic intervention with medicinal substances, and associated foundational theoretical concepts. Prerequisites: Permission of the instructor.

1-3 credits; maximum, 10 credits. Applicable to all disciplines.

(1-9 cr) Grades of CR (Credit) or NC (No Credit) will be awarded. Applicable to all disciplines. May be repeated for credit.