faculty portrait if available
Paul Sylvester
Professor
Pharmacy Administration
PHAR 344
318-342-1958
ULM logo

Paul W Sylvester, PhD
Professor, Pharmacy
Director of Graduate Studies and Research (Pharmacy)

Education

Ph D

1982, Physiology
Michigan State University

BS

1976, Biology
Western Michigan University

faculty feature photo

Biographical Sketch

Dr. Sylvester received his B.S. degree in biology from Western Michigan University in Kalamazoo, MI, his Ph.D. from Michigan State University in East Lansing, MI, and received postdoctoral training at Roswell Park Cancer Institute in Buffalo, NY.  Prior to his arrival at ULM, Dr. Sylvester was a faculty member for ten years in the College of Pharmacy at Washington State University in Pullman, WA.  Dr. Sylvester is an endocrinologist and his research interests have focused on endocrine-dependent diseases, particularly breast cancer.  Dr. Sylvester’s laboratory is currently examining the mechanisms mediating the antiproliferative and apoptotic effects of tocotrienols, a rare natural form of vitamin E, in breast cancer cells.  Dr. Sylvester has maintained an active research program supported by grants from the National Cancer Institute at NIH, American Cancer Society, and American Institute of Cancer Research, and First Tech International Ltd, Louisiana Cancer Foundation, among others.  Dr. Sylvester has authored over 140 peer reviewed research publications, 21 book chapters, and has presented more than 154 talks at national and international scientific conferences.  Dr. Sylvester was awarded eight teaching awards during the past 24 years.  

Research Interests

  Our laboratory has been involved in breast cancer research for many years that has focused on developing tocotrienols, a natural form of vitamin E, as a clinical treatment for breast cancer in women.  My research will provide information that will determine the potential health benefits of various natural products in the prevention and/or treatment of breast cancer in women.  We also received research grants this past year from the Louisiana Cancer Foundation.  

Recent Publications

Sylvester, P. W., Sultana, T., Aldabaan, N., Anwar, M. R., Grazier, J. J., Sylvester, P. W. (2020). Intracellular Mechanisms Involved in Mediating -Tocotrienol Reversal of Epithelial-to Mesenchymal Transition (EMT) in Breast Cancer Cells. (pp. 159-186). New York, NY: Horizons in Cancer Research/Nova Science Publishers.
Ibrahim, M. M., Bheemanapally, K., Sylvester, P. W., Briski, K. P. (2020). Norepinephrine Regulation of Adrenergic Receptor Expression, 5’ AMP-Activated Protein Kinase Activity, and Glycogen Metabolism and Mass in Male versus Female Hypothalamic Primary Astrocyte Cultures. (pp. 1759091420974130). Molecular and Cellular Endocrinology.
Ibrahim, M. M., Bheemanapally, K., Sylvester, P. W., Briski, K. P. (2020). Sex Differences in Glucoprivic Regulation of Glycogen Metabolism in hypothalamic primary astrocyte cultures: Role of Estrogen Receptor Signaling. (pp. 111000). Molecular and Cellular Endocrinology.
Ibrahim, M., Bheemanapally, K., Sylvester, P. W., Briski, K. P. (2020). Sex-specific estrogen regulation of hypothalamic astrocyte estrogen receptor expression and glycogen metabolism in rats (pp. 110703). Monroe: Molecular and Cellular Endocrinology.
Sylvester, P. W., Dronamraju, V. (2020). -Tocotrienol reversal of the Warburg effect in breast cancer cells is associated with 5”-AMP-activated kinase activation. (pp. 416-436). Philadelphia: Molecular Nutrition of Vitamins/Elsevier Publishing..
Sylvester, P. W. (2019). Role of Lipid Rafts in Mediating the Anticancer Effects of -Tocotrienol (pp. 125-140). Totowa NJ: Vitamin E in Human Health/Humana Press.
Ahmed, R., Sylvester, P. W. (2019). γ-Tocotrienol reversal of epithelial-to-mesenchymal transition in human breast cancer cells is mediated through a suppression of canonical Wnt and Hedgehog signaling pathways. (pp. 83-100). London: InTech Publications.
Dronamraju, V., Ibrahim, B. A., Briski, K. P., Sylvester, P. W. (2019). γ-Tocotrienol Negative Modulation of the Warburg Effect is Mediated by the AMPK Activation in Malignant Breast Cancer Cells. (pp. 1214-1228). West Monroe: Nutrition and Cancer: An International Journal.
Briski, K. P., Alenazi, F., Shakya, M., Sylvester, P. W. (2017). Hindbrain A2 Noradrenergic Neuron Adenosine 5’-Monophosphate-Activated Protein Kinase (AMPK) Activation, Upstream Kinase/Phosphorylase Protein Expression, and Receptivity to Hormone and Fuel Reporters of Short-Term Food Deprivation are Regulated by Estradiol. (pp. 1427-1437). Journal of Neuroscience.
Sylvester, P. w., Tiwari, R. V. (2016). Role of Autophagy in Mediating the Anticancer Effects of Tocotrienols. (pp. 89-104). Rijeka: Autophagy in Current Trends in Cellular Physiology and Pathology.
Alawin, O. A., Ahmed, R. R., Dronamraju, V., Algayadh, I. G., Kalloub, A. A., Sylvester, P. W. (2016). Role of Endoplasmic Retiulum Stress in Mediating the Anticancer Effects of Tocotrienols. (pp. 101-128). Hauppauge, NY.: Nova Science Publisher.
Alawin, O. A. (2017). γ-Tocotrienol-Induced Disruption of Lipid Rafts in Human Breast Cancer Cells is Associated with a Reduction in Exosome Heregulin Content. Journal of Nutrition and Biochemistry.
Briski, K. P., Alenazi, F., Shakya, M., Sylvester, P. W. (2017). Hindbrain A2 Noradrenergic Neuron Adenosine 5’-Monophosphate-Activated Protein Kinase (AMPK) Activation, Upstream Kinase/Phosphorylase Protein Expression, and Receptivity to Hormone and Fuel Reporters of Short-Term Food Deprivation are Regulated by Estradiol. Journal of Neuroscience.
Algayadh, E. G., Dronamraju, V., Sylvester, P. W. (2016). gamma-Tocotrienol Inhibition of Cell Migration and Invasion Is Associated With a Suppression in WAVE 2 Signaling in Highly Malignant Breast Cancer Cells. (pp. 1974-1982). Biological and Pharmaceutical Bulletin.
Ahmed, A. R., Alawin, O. A., Sylvester, P. W. (2016). γ-Tocotrienol reversal of Epithelial-to-Mesenchymal Transition in Human Breast Cancer Cells is Associated with an Inhibition in Canonical Wnt Signaling. (pp. 460-470). Cell Proliferation.
Klionsky, D. J., Abdelmoshsen, K., Abe, A. (2016). 136. Klionsky, D.J., Abdelmoshsen, K., Abe, A., et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3nd edition). (pp. 1-222). Autophagy.
Alawin, O. A., Ahmed, R. A., Ibrahim, B. A., Briski, K. P., Sylvester, P. W. (2016). Antiproliferative effects of γ-tocotrienol are associated with lipid raft disruption in HER2 positive breast cancer cells. (pp. 266-277). Journal of Nutritional Biochemistry.
Tiwari, R. V., Parajuli, P., Sylvester, P. W. (2015). Tiwari, R.V., Parajuli, P. and Sylvester, P.W. (2015) Synergistic Anticancer Effects of Combined γ-Tocotrienol and Oridonin Treatment is Associated with the Induction of Autophagy. (pp. 123-137). Molecular and Cellular Biochemistry.
Parajuli, P., Tiwari, R. V., Sylvester, P. W. (2015). Anticancer Effects of γ-Tocotrienol are Associated with a Suppression in Aerobic Glycolysis (pp. 1352-1360). Biological and Pharmaceutical Bulletin..
Parajuli, P., Tiwari, R. V. (2015). Antiproliferative Effects of γ-Tocotrienol are Associated with a Suppression in c-Myc Expression in Mammary Tumor Cells”. (pp. 421-432). Cell Proliferation.
Alqahtani, S., Simon, L., Alayoubi, A., Sylvester, P. W., Nazzal, S., Shen, Y., Xu, Z., Kaddoumi, A., Sabliov, C. M. (2015). (pp. 243-251). Journal of Colloid and Interface Science.
Sylvester, P. W. (2014). Combined γ-Tocotrienol and Met Inhibitor Treatment Suppresses Mammary Cancer Cell Proliferation, Epithelial-to-Mesenchymal Transition, and Migration. (pp. 18-30). Journal of Oil Palm, Environment & Health.
Tiwari, R., Parajuli, P., Sylvester, P. (2015). γ-Tocotrienol-Induced Autophagy Promotes Endoplasmic Reticulum Stress Mediated Apoptosis in Breast Cancer. (pp. 306-320). Biochemistry and Cell Biology.
Sylvester, P. (2014). Targeting Met mediated epithelial-mesenchymal transition in the treatment of cancer. (pp. http://www.clintransmed.com/content/3/1/30). Clinical and Translational Medicine.
Ananthula, S., Parajuli, P., Behery, F. A., El Sayed, K. A., Sylvester, P. W. (2014). δ-Tocotrienol Oxazine Derivative Antagonizes Mammary Tumor Cell Compensatory Responses to CoCl2-Induced Hypoxia. (pp. doi: 10.1155/2014/285752.). Biomed Res International.
Aayoubi, A., Abu-Fayyad, A., Rawas-Qalaji, M., Sylvester, P., Nazzal, S. (2014). Effect of lipid viscosity and high-pressure homogenization on the physical stability of “Vitamin E” enriched emulsion. (pp. 555-561). Pharmaceutical Development and Technology.
Alqahtani, S., Alayoubi, A., Nazzal, S., Sylvesterr, P. W., Kaddoumi, A. (2014). Enhanced solubility and oral bioavailability of γ-tocotrienol using a self-emulsifying drug delivery system (SEDDS). (pp. 819-829). Lipids.
Ananthula, S., Parajuli, P., Behery, F., Alayoubi, A., El Sayed, K., Nazzal, S., Sylvester, P. (2014). Oxazine Derivatives of γ- and δ- Tocotrienol Display Enhanced Anticancer Activity In Vivo (pp. 2715-2726). Anticancer Research.
Alayoubi, A., Ayoub, N., Malaviya, A., Sylvester, P., Nazzal, S. (2014). Entrapment Into Nanoemulsions Potentiates the Anticancer Activity of Tocotrienols Against the Highly Malignant (+SA) Mouse Mammary Epithelial Cells. (pp. 4002-4005). Journal of Nanoscience and Nanotechnology.
Malaviya, A., Sylvester, P. (2014). Antiproliferative Effects of combined treatment of γ–Tocotrienol with PPARγ Agonists or Antagonists mediated through PPARγ-independent mechanisms in breast cancer cells. (pp. http://dx.doi.org/10.1155/2014/439146.). PPAR Research.
Sylvester, P., Ananthula, S., Parajuli, P., Akl, M., Malaviya, A., Tiwari, R., Ayoub, N. (2014). Potential role of tocotrienols in the treatment and prevention of breast cancer. (pp. 49-58). Biofactors.
Tiwari, R., Parajuli, P., Sylvester, P. (2014). gamma-Tocotrienol-Induced Autophagy in Malignant Mammary Cancer Cells. (pp. 33-44). Experimental Biology and Medicine.
Ayoub, N., Sylvester, P. (2013). Combined γ-Tocotrienol and Met Inhibitor Treatment Suppresses Cancer Cell Proliferation, Epithelial-to-Mesenchymal Transition, and Migration. (pp. 538-553). Cell Proliferation.
Sylvester, P., Ayoub, N. (2013). Tocotrienols Target PI3K/Akt Signaling in Anti-Breast Cancer Therapy. (pp. 1039-1047). Anti-Cancer Agents in Medicinal Chemistry.
Alqahtani, S., Alayoubi, A., Nazzal, S., Sylvester, P., Kaddoumi, A. (2013). Non-Linear Absorption Kinetics of Self-Emulsifying Drug Delivery Systems (SEDDS) Containing Tocotrienols as Lipophilic Molecules: In Vivo and In Vitro Studies. American Association of Pharmaceutics Journal.
Malaviya, A., Parajuli, P., Sylvester, P. (2014). Synergistic Antiproliferative Effects of Combined PPARγ Antagonist and γ-Tocotrienol Treatment Suppress Adipogenic Factors in Breast Cancer Cells. JPANS.
Alayoubi, A., Nazzal, M., Sylvester, P., Nazzal, S. (2013). Vitamin E” fortified parenteral lipid emulsions: Plackett-Burman screening of primary process and composition parameters. (pp. 363-373). Drug Development and Industrial Pharmacy.
Alayoubi, A., Kanthala, S., Satyanarayanajois, S., Anderson, J., Sylvester, P., Nazzal, S. (2013). Stability and in vitro antiproliferative activity of bioactive “Vitamin E” fortified parenteral lipid emulsions (pp. 23-30). Colloids and Surfaces B: Biointerfaces.
Sylvester, P. W., Shah, S., Haynie, D., Briski, K. (2005). Effects of ultra-wide band electromagnetic pulses on pre-neoplastic mammary epithelial cell proliferation. (pp. 153-163). Cell Proliferation.
Ali, H., Shirode, A., Sylvester, P. W., Nazzal, S. (2010). Preparation and In Vitro Antiproliferative Effect of Tocotrienol Loaded Lipid Nanoparticles. Colloids and Surfaces A: Physicochemical and Engineering Aspects.
Akl, M. R., Sylvester, P. W. (2013). Anticancer Activity of Boswellia (Frankincense) Essential Oil. In: Recent Progress in Medicinal Plants, Volume 38, “Essential Oil III and Phytopharmacology, (pp. 43-58). The Stadium Press LLC (USA), Houston, TX..
Malaviya, A., Sylvester, P. W. (2013). Mechanisms mediating the effects of γ–tocotrienol used in combination with PPARγ agonists or antagonists on MCF-7 and MDA-MB-231 breast cancer cell proliferation. International Journal of Breast Cancer.
Ayoub, N. M., Akl, M. R., Sylvester, P. W. (2013). Combined -Tocotrienol and Met Inhibitor Treatment Suppresses Cancer Cell Proliferation, Epithelial-to-Mesenchymal Transition, and Migration. Cell Proliferation.
Ayoub, N. M., Akl, M. R., Sylvester, P. W. (2013). Combined -Tocotrienol and Met Inhibitor Treatment Suppresses Cancer Cell Proliferation, Epithelial-to-Mesenchymal Transition, and Migration. Cell Proliferation.
Alayoubi, A., Anderson, J. F., Satyanarayana-Jois, S., Sylvester, P. W., Nazzal, S. (2013). Concurrent delivery of tocotrienols and simvastatin by lipid nanoemulsions potentiates their antitumor activity against human mammary adenocarcenoma cells (pp. 385-392). European Journal of Pharmaceutical Sciences.
Behery, F. A., Akl, M. R., Elnagar, A. Y., Ananthula, S., Parajuli, P., Kaddoumi, A., Sylvester, P. W., El Sayed, K. A. (2013). Mannich and Lederer-Manasse-based semisynthetic products of - and -tocotrienols as inhibitors of breast cancer cell proliferation and migration. Bioorganic and Medicinal Chemistry.
Malaviya, A., Sylvester, P. W. (2013). Mechanisms mediating the effects of γ–tocotrienol used in combination with PPARγ agonists or antagonists on MCF-7 and MDA-MB-231 breast cancer cell proliferation. (pp. http://dx.doi.org/10.1155/2013/101705). International Journal of Breast Cancer.
Akl, M. M., Ayoub, N. M., Sylvester, P. W. (2013). Mechanisms mediating the synergistic anticancer effects of combined gamma-tocotrienol and sesamin treatment. (pp. 1731-1739). Planta Medica.
Alqahtani, S., Alayoubi, A., Nazzal, S., Sylvester, P. W., Kaddoumi, A. (2013). Non-Linear Absorption Kinetics of Self-Emulsifying Drug Delivery Systems (SEDDS) Containing Tocotrienols as Lipophilic Molecules: (pp. doi: 10.1208/s12248-013-9481-7). American Association of Pharmaceutics Journal.
Saeed, A., Alaadin, A., Nazzal, S., Sylvester, P. W., Khalil, A. (2013). Nonlinear Absorption Kinetics of Self-Emulsifying Drug Delivery Systems (SEDDS) Containing Tocotrienols as Lipophilic Molecules: In Vivo and In Vitro Studies. AAPS Journal.
Sylvester, P. W., Ananthula, S., Parajuli, P., Akl, M. M., Malaviya, A., Tiwari, R. A., Alawin, O., Ayoub, N. M. (2013). Potential role of tocotrienols in the treatment and prevention of breast cancer. Biofactors.
Alayoubi, A., Kanthala, S., Satyanarayana-Jois, S., Anderson, J. F., Sylvester, P. W., Nazzal, S. (2013). Stability and in vitro antiproliferative activity of bioactive “Vitamin E” fortified parenteral lipid emulsions (pp. 23-30). Colloids and Surfaces B: Biointerfaces.
Sylvester, P. W. (2013). Tocotrienols and Cancer. Biofactors.
Sylvester, P. W., Ayoub, N. M. (2013). Tocotrienols Target PI3K/Akt Signaling in Anti-Breast Cancer Therapy. (pp. 1039-1047). Anti-Cancer Agents in Medicinal Chemistry.
Alayoubi, A., Nazzal, M., Sylvester, P. W., Nazzal, S. (2013). “Vitamin E” Fortified Parenteral Lipid Emulsions: Plackett-Burman Screening of Primary Process and Composition Parameters (pp. 363-373). Drug Development and Industrial Pharmacy.
El Sayed, K., Sylvester, P. W. (2013). Discovery and optimization of tocotrienol electrophilic substitution products as antiproliferative and antimigratory leads (pp. 329-341). European Journal of Medicinal Chemistry-Elsevier.
Abuasal, B. S., Qosa, H., Sylvester, P. W., Kaddoumi, A. (2012). Comparison of the intestinal absorption and bioavailability of α-tocopherol and γ-tocotrienol: in-vitro, in-situ, and in-vivo studies. (pp. 246-256). Drug Metabolism & Disposition.
Bilal, A., Hisham, Q., Sylvester, P. W., Khalil, A. (2012). Comparison of the intestinal absorption and bioavailability of γ-tocotrienol and α-tocopherol: in-vitro, in-situ, and in-vivo studies (pp. 246-56). Biopharm Drug Dispos.
Alayoubi, A., Anderson, J. F., Satyanarayanajois, S. D., Sylvester, P. W., Nazzal, S. (2012). Concurrent delivery of tocotrienols and simvastatin by lipid nanoemulsions potentiates their antitumor activity against human mammary adenocarcinoma cells. (pp. 386-392). European Journal of Pharmaceutical Sciences.
Abuasal, B. S., Lucas, C., Peyton, B., Alayoubi, A., Nazzal, S., Sylvester, P. W., Kaddoumi, A. (2012). Enhancement of intestinal permeability utilizing solid lipid nanoparticles increases γ-tocotrienol oral bioavailability (pp. 461-469). Lipids.
Bilal, A., Courtney, L., Breanne, P., Alaadin, A., Nazzal, S., Sylvester, P. W., Khalil, A. (2012). Enhancement of Intestinal Permeability Utilizing Solid Lipid Nanoparticles Increases γ-Tocotrienol Oral Bioavailability (pp. 461-9). Lipids.
Sylvester, P. W., Malaviya, A., Ananthula, S., Parash, P., Tiwari, R. (2012). In: Statins: Pharmacology, Clinical Implications and Adverse Effects, (pp. 125-150). Nova Science Publishers, Inc., Hauppauge, NY..
Alayoubi, A., Satyanarayanjois, S. D., Sylvester, P. W., Nazzal, S. M. (2012). Molecular Modeling and Multisimplex Optimization of Tocotrienol-Rich Self Emulsified Drug Delivery Systems. (pp. 153-161). International Journal of Pharmaceutics.
Alayoubi, A., Satyanarayana-Jois, S., Sylvester, P. W., Nazzal, S. (2012). Multisimplex Optimization of Tocotrienol-Rich Self Emulsified Drug Delivery Systems (pp. 153-161). International Journal of Pharmaceutics.
Behery, F. A., Akl, M. R., Ananthula, S., Sylvester, P. W., El Sayed, K. A. (2012). Optimization of tocotrienols as antiproliferative and antimigratory leads. (pp. 329-341). European Journal of Medicinal Chemistry.
Akl, M. R., Ayoub, N. M., Abuasal, B., Kaddoumi, A., Sylvester, P. W. (2012). Sesamin synergistically potentiates the anticancer effects of gamma-tocotrienol in mammary tumor cell lines. (pp. 347-359). Fitoterapia.
Alayoubi, A., Kanthala, S., Satyanarayanajois, S. D., Anderson, J. F., Sylvester, P. W., Nazzal, S. (2012). Stability and in vitro antiproliferative activity of bioactive “Vitamin E” fortified parenteral lipid emulsions. (pp. 23-30). Colloids and Surfaces B: Biointerfaces.
Sylvester, P. W. (2012). Synergistic Anticancer Effects of Combined -Tocotrienol with Statin or Receptor Tyrosine Kinase Inhibitor Treatment in Mammary Tumor Cells (pp. 63-74). Genes & Nutrition.
Sylvester, P. W. (2012). Tocotrienol Loaded Lipid Nanoparticles in Cancer. In: Nanomedicine and Cancer, (pp. 63-83). Science Publishers/CRC Press Taylor & Francis Group.
Alayoubi, A., Nazzal, M., Sylvester, P. W., Nazzal, S. (2012). “Vitamin E” fortified parenteral lipid emulsions: Plackett-Burman screening of primary process and composition parameters. (pp. 363-373). Drug Development and Industrial Pharmacy.
Elnagar, A. Y., Sylvester, P. W., El Sayed, K. A. (2011). (-)-Oleocanthal as a c-met inhibitor for the control of metastatic breast and prostate cancers. (pp. 1-7). Planta Medica.
Bilal, A., Shawn, T., Sylvester, P. W., Khalil, A. (2011). Development and validation of a reversed phase HPLC method for the determination of γ-tocotrienol in rat and human plasma (pp. 621-7). Biomedical Chromatography.
Sylvester, P. W., Wali, V. B., Bachawal, S. V., Shirode, A. B., Ayoub, N. M., Akl, M. R. (2011). Frontiers in Bioscience (pp. 3183-3195). Frontiers in Bioscience.
Alaa, A. H., Hisham, Q., Nick, O. D., Jessica, A., Sylvester, P. W., El Sayed, K., Khalil, A. (2011). Induction of expression and functional activity of P-glycoprotein efflux transporter by bioactive plant natural products (pp. 2765-72). Food Chem Toxicol.
Shirode, A. B., Sylvester, P. W. (2011). Mechanisms mediating the synergistic anticancer effects of combined -tocotrienol and celecoxib treatment. Journal of Bioanalysis & Biomedicine. 3:001-007. doi:10.4172/1948-593x.1000036: Journal of Bioanalysis & Biomedicine.
Sylvester, P. W. (2011). Optimization of the tetrazolium dye (MTT) colorimetric assay for cellular growth and viability. In: Drug Design and Discovery: Methods and Protocols, Methods in Molecular Biology, (pp. 157-168). Humana Press, New York, NY..
Sylvester, P. W. (2011). Tocotrienol Dietary Supplementation and Health. In: Vitamin E: Nutrition, Side Effects and Supplements, (pp. 1-43). Nova Science Publishers, Inc., Hauppauge, NY..
Elnagar, A., Wali, V., Sylvester, P. W., El Sayed, K. (2010). ) Design and Preliminary Structure-Activity Relationship of Redox-Silent Semisynthetic Tocotrienol Analogues as Inhibitors for Breast Cancer Proliferation and Invasion. (pp. 755-768). Bioorganic & Medicinal Chemistry.
AbuAsal, B., Sylvester, P. W., Kaddoumi, A. (2010). Characterization of γ-Tocotrienol Intestinal Permeability and Metabolism Using in situ Rat Intestinal Perfusion Model. Journal of Lipid Research.
Bachawal, S., Wali, V., Sylvester, P. W. (2010). Combined gamma-tocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in mammary tumor cells. (pp. 429-438). Anticancer Research.
Abdel Bar, F., Khanfar, M., Elnagar, A., Badria, F., Zaghloul, A., Ahmad, K., Sylvester, P. W., El Sayed, K. (2010). Design and Pharmacophore Modeling of Microtubule-Disrupting Biaryl Methyl Eugenol Analogs as Breast Cancer Invasion Inhibitors. Bioorganic Medicinal Chemistry (pp. 496-507). Bioorganic Medicinal Chemistry.
Ali, H., Shirode, A., Sylvester, P. W., Nazzal, S. (2010). Preparation and In Vitro Antiproliferative Effect of Tocotrienol Loaded Lipid Nanoparticles. (pp. 223-231). International Journal of Pharmaceutics.
Sylvester, P. W., Ayoub, N. M., Akl, M. R. (2010). Role of Natural Vitamin E in Breast Cancer Prevention and Treatment. (pp. 157-168). Nova Science Publishers, Inc., Hauppauge, NY..
Behery, F., Elnagar, A., Wali, V., Abouasal, B., Akl, M., Khalil, A., Sylvester, P. W., El Sayed, K. (2010). Redox-Silent Tocotrienol Esters as Breast Cancer Proliferation and Migration Inhibitors (pp. 8066-8075). New York: Bioorganic & Medicinal Chemistry, Elsevier.
Abuasal, B., Sylvester, P. W., Khalil, A. (2010). Intestinal Absorption of γ-Tocotrienol is Mediated by NPC1L1: In Situ Rat Intestinal Perfusion Studies. Drug Metabolism & Disposition.
Abuasal, B., Sylvester, P. W., Khalil, A. (2011). Development and validation of a reversed phase HPLC method for the determination of y-tocotrienol in rat and human plasma (pp. 621-627). Biomedical Chromatography.
Abdelbar, F., El Sayed, K., Sylvester, P. W., Raisch, K., Zaghloul, A., Badria, F., Mohammad, K., Elnagar, A. (2010). Design and pharmacophore modeling of microtubule-disrupting biaryl methyl eugenol analogs as breast cancer invasion inhibitors (pp. 496–507). Bioorganic Medicinal Chemistry/Elsevier.
Elnagar, A., Sylvester, P. W., Wali, V., El Sayed, K. (2009). Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion. (pp. 755-768). New York: Bioorganic & Medicinal Chemistry.
Paatwardhan, G., Zhang, Q., Yin, D., Gupta, V., Bao, J., Xie, P., Senkal, P., Ogretmen, B., Cabot, M., Shah, G., Sylvester, P. W., Jazsinski, S., Liu, Y. (2009). A New Mixed-Backbone Oligonucleotide against Glucosylceramide Synthase Sensitizes Multidrug-Resistant Tumors to Apoptosis. (pp. e6938). PLoS One.
Samant, G. V., Wali, V. B., Sylvester, P. W. (2009). Antiproliferative Effects of -Tocotrienol on Mammary Tumor Cells are Associated with a Suppression in Cell Cycle Progression. Cell Proliferation.
Wali, V. B., Bachawal, S. V., Sylvester, P. W. (2009). Combined Treatment of -Tocotrienol with Statins Induce Mammary Tumor Cell Cycle Arrest in G1 (pp. 639-650). Experimental Biology and Medicine.
Wali, V., Bachawal, S., Sylvester, P. W. (2009). Endoplasmic Reticulum Stress Mediates -Tocotrienol-Induced Apoptosis in Mammary Tumor Cells (pp. 1366-1377). Apoptosis.
Bachawal, S., Wali, V., Sylvester, P. W. (2009). Enhanced Antiproliferative Response to Combined -Tocotrienol and Erlotinib or Gefitinib Treatment in Mammary Tumor Cells. BioMedical Central Cancer.
Sylvester, P. W., Samant, G. V., Wali, V. B., Bachawal, S. V. (2009). Intracellular Mechanisms Mediating Vitamin E Suppression of Mammary Tumor Cell Proliferation. (pp. 371-388). Nova Science Publishers, Inc., Hauppauge, NY: Handbook of Cell Proliferation.
Abdel Bar, F., Khanfar, M., Elnagar, A., Liu, H., Zahloul, A., Badria, F., Sylvester, P. W., Ahmad, D., Raisch, K., El Sayed, K. (2009). Rational Design and Semisynthesis of Betulinic Acid Analogues as Potent Topoisomerase Inhibitors. (pp. 1643-1650). Journal of Natural Products.
Radwan, M., Manly, S., El Sayed, K., Wali, V., Sylvester, P. W., Awate, B., Shah, G., Ross, S. (2009). Sinulodurins A and B, Antiproliferative and Anti-invasive Diterpenes from the Soft Coral Sinularia dura. (pp. 1468-1471). Journal of Natural Products.
Wali, V., Bachawal, S., Sylvester, P. W. (2009). Suppression in mevalonate synthesis mediates the antitumor effects of combined statin and -tocotrienol treatment. (pp. 925-934). Lipids.
Shirode, A. V., Sylvester, P. W. (2009). Synergistic antiproliferative effect of -tocotrienol and celecoxib on mammary tumor cells is associated with a suppression in Akt and NFκB Signaling. Biomedicine and Pharmacotherapy.
El Sayed, K., Elnagar, A., Wali, V., Sylvester, P. W. Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion. New York: Bioorganic & Medicinal Chemistry-.
Abdel Bar, F. A., Khanfar, M. A., H, L., Raisch, K. P., Sylvester, P. W., Zaghloul, A. M., Badria, F. A., El Sayed, K. (2009). Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors (pp. 1643-1650). Washington DC/American Chemical Society: Journal of Natural Products.
Sylvester, P. W. (2008). Antiproliferative and Apoptotic Effects of Tocotrienols on Normal and Neoplastic Mammary Epithelial Cells (pp. 119-140). AOCS Press, Champaign, IL.: Tocotrienols: Vitamin E Beyond Tocopherols.
Abdel Bar, F., Zaghloul, A., Bachawal, S., Sylvester, P. W., Khanfar, M., El Sayed, K. (2008). Antiproliferative Triterpenes from Melaleuca ericifolia (pp. 1787-1790). Journal of Natural Products.
Sylvester, P. W., Bachawal, S. V., Wali, V. B., Shirode, A. V. (2008). Epidermal Growth Factor Receptor Dependent Mitogenic Signaling in Normal and Malignant Mammary Epithelial Cells. (pp. 139-157). Nova Science Publishers, Inc., Hauppauge, NY: Cellular Growth Processes.
El Sayed, K., Laphookhieo, S., Yousaf, M., Prestridge, J., Shirode, A., Wali, V., Sylvester, P. W. (2008). Semisynthetic and biocatalytic anticancer optimization of tobacco (1S, 2E, 4S, 6R, 7E, 11E) – 2,7,11-cembratriene-4,6-diol (pp. 117-122). Journal of Natural Products.
Radwan, M., Manly, S., El Sayed, K., Wali, V., Sylvester, P. W., Awate, B., Shah, G., Ross, S. (2008). Sinulodurins A and B, Antiproliferative and Anti-invasive Diterpenes from the Soft Coral Sinularia dura (pp. 1468-1471). Journal of Natural Products.
Sawant, S., Youssef, D., Sylvester, P. W., Wali, V., El Sayed, K. (2007). Antiproliferative sesquiterpenes from the Red Sea soft coral Sarcophyton glaucum. (pp. 177-199). Natural Product Communications.
Jain, S., Shirode, A., Yacoub, S., Barbo, A., Sylvester, P. W., Huntimer, E., Halaweish, F., El Sayed, K. (2007). Biocatalysis of the anticancer sipholane triterpenoids (pp. 1-6). Planta Medica.
El Sayed, K., Sylvester, P. W. (2007). Biocatalytic and semisynthetic studies of the anticancer tobacco cembranoids. (pp. 877-887). Expert Opinions on Investigational Drugs.
Sylvester, P. W. (2007). Mechanisms Mediating Vitamin E-Induced Apoptosis in Mouse Mammary Tumors. (pp. 53-66). Nova Science Publishers, Inc., Hauppauge, NY.: New Cell Apoptosis Research.
Wali, V. B., Sylvester, P. W. (2007). Synergistic antiproliferative effects of -tocotrienol and statin treatment on mammary tumor cells (pp. 1113-1123). Lipids.
Sylvester, P. W., Wali, V., Shirode, A., Bachawal, S., El Sayed, K. (2007). Tocotrienols Are the Most Potent Anticancer Agents in the Vitamin E Family of Compounds (pp. 55-75). Current Research in Cancer.
Sylvester, P. W. (2007). Vitamin E and Apoptosis. Elsevier Inc, San Diego, CA.: Vitamins and Hormones.
Sawant, S., Youseff, D., Mayer, A., Sylvester, P. W., Wali, V., Arant, M., El Sayed, K. (2006). Anticancer and anti-inflammatory sulfur-containing semisynthetic derivatives of sarcophine (pp. 1119-1123). Chemical and Pharmaceutical Bulletin.
Sylvester, P. W. (2006). Targeting the PI3K/PDK/Akt Signaling Pathway in Anticancer Therapy. In: (pp. 173-190). . Nova Science Publishers, Inc., Hauppauge, NY.: Trends in Signal Transduction Research.
Sylvester, P. W. (2006). -Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signaling in of neoplastic mammary epithelial cells. (pp. 563-574). Cell Proliferation.
Shah, S., Sylvester, P. W. (2005). Antiproliferative effects of -tocotrienol are associated with a reduction in Akt and NFkB activity (pp. 235-241). Experimental Biology and Medicine..
Sylvester, P. W., Shah, S. (2005). Intracellular mechanisms mediating tocotrienol-induced apoptosis in neoplastic mammary epithelial cells (pp. 366-373). Asian Pacific Journal of Clinical Nutrition.
Sylvester, P. W., Shah, S., Samant, G. (2005). Intracellular signaling mechanisms mediating the antiproliferative and apoptotic effects of -tocotrienol in neoplastic mammary epithelial cells. (pp. 803-810). Journal of Plant Physiology.
Sylvester, P. W., Shah, S. (2005). Mechanisms mediating the antiproliferative and apoptotic effects of vitamin E in mammary cancer cells (pp. 699-709). Frontiers In Bioscience.
Shah, S., Sylvester, P. W. (2005). Tocotrienol-induced cytotoxicity is unrelated to mitochondrial stress apoptotic signaling in neoplastic mammary epithelial cells. (pp. 86-95). Biochemistry and Cell Biology.

Research Grants

Sylvester, P. W., "Cancer Research Grant" (Funded), Sponsored By Louisiana Cancer Foundation, External to The University of Louisiana at Monroe, $10,000. (January 1 2020 - December 31 2020).
Sylvester, P. W., "Cancer Research Grant" (Funded), Sponsored By Louisiana Cancer Foundation, External to The University of Louisiana at Monroe, $10,000. (2019).
El Sayed, K. (Principal), Sylvester, P. W. (Co-Principal), Liu, Y. (Co-Principal), "Design of novel c-Met inhibitors inspired by olive phenolics-1R15CA167475-01" (Funded), Sponsored By NIH/NCI, External to The University of Louisiana at Monroe, $420540. (February 01 2013 - January 31 2016).
Sylvester, P. (Principal), "Breast Cancer Research" (), Sponsored By Louisiana Cancer Foundation, External to The University of Louisiana at Monroe, $20000. (October 2013 - October 2014).
Sylvester, P. W., "Cancer Research Grant" (Funded), Sponsored By Louisiana Cancer Foundation., External to The University of Louisiana at Monroe, $10000. (January 2013 - January 2014).
Sylvester, P. W., "Optimization of Tocotrienol Extraction and Purification From Rice Bran Oil for use in the Prevention and Treatment of Breast Cancer." (Funded), Sponsored By Louisiana Campuses research Initiative (LACRI) 2012, The University of Louisiana at Monroe, $20000. (January 1 2013 - December 31 2013).
Sylvester, P. (Principal), "Breast Cancer Research" (), Sponsored By Louisiana Cancer Foundation, External to The University of Louisiana at Monroe, $10000. (July 2012 - June 2013).

Patents

Sylvester, P. (2016). Tocotrienol Derivatives and Associated Methods. US Patent No. French Patent Number EP2785722.

Sylvester, P. (2016). Tocotrienol Derivatives and Associated Methods. . US Patent No. German Patent Number 2785722.

Sylvester, P. (2016). Tocotrienol Derivatives and Associated Methods. . US Patent No. United Kingdom Patent Number EP2785722.

Sylvester, P. (2015). El Sayed, K.A. and Sylvester, P.W. Tocotrienol Esters.. US Patent No. 8969303.

Sylvester, P. (2014). El Sayed, E.A., Sylvester, P.W. and Behery, F. Tocotrienol Derivatives and Associated Methods.. US Patent No. 8816071.

Sylvester, P. (2011). Patents El Sayed, K.A., Shah, G., and Sylvester, P.W. Anticancer Tobacco Cembranoids, Submitted 12/18/08.. US Patent No. 7977384.

Sylvester, P. (2014). Sylvester, P.W. and El Sayed, K.A. Anticancer Tocotrienol Analogues and Associated Methods, Submitted 5/11/09.. US Patent No. 8266786.

Awards & Honors

August 2011 ULM Foundation Award for Excellence in Research.

October 2007 Outstanding Professor In the College of Pharmacy.

2006 Teacher of the Year.

2006 Excellence in Teaching.

2005 Teacher of the Year.

2003 Outstanding Faculty Member in the College of Pharmacy.

1998 Teacher of the Year.

1997 Teacher of the Year.

1996 Teacher of the Year.

1993 Teacher of the Year.

Courses Taught

PHAR 4013Pharmacology III, 4 course(s)

PHAR 5016STERILE PRODUCTS, 1 course(s)

PHAR 5021ADVANCED PHARMACOLOGY, 8 course(s)

PHAR 5022Adv Pharmacology Lab, 1 course(s)

PHAR 5052SEMINAR, 35 course(s)

PHRD 4010INTRODUCTION TO PHARMACY, 6 course(s)

PHRD 4012PATHOPHYSIOLOGY I, 4 course(s)

PHRD 4027PRINCIPLES OF DRUG ACTION II, 6 course(s)

PHRD 4035PATHOPHYSIOLOGY II, 7 course(s)

PHRD 4058NEUROLOGY & PSYCHIATRY MODULE, 8 course(s)

PHRD 4072THERAPEUTICS II, 2 course(s)

PHRD 4074ENDOCRINE MODULE, 6 course(s)

PHRD 5014THERAPEUTICS V, 2 course(s)

PHRD 5027BONE AND JOINT MODULE, 5 course(s)

PHRD 5061WOMEN'S HEALTH AND PHARMACIST, 5 course(s)

PHRD 5064PROBLEMS, 10 course(s)

TOXI 4001GENERAL LAB TECHNIQUES, 1 course(s)