faculty portrait if available
Sharon Meyer
Professor
School Basic Pharm & Toxicol Sci
PHAR 262
318-342-1685
ULM logo

Sharon A Meyer, PhD
Professor, Toxicology

Education

Ph D

1984, Physiology
Cornell University

MS

1977, Biochemistry
Iowa State University

BS

1971, Chemistry
Iowa State University

faculty feature photo

Biographical Sketch

Dr. Sharon A. Meyer, Ph.D., ATS fellow, has worked in academic research/teaching for 25 years.  She has degrees in Chemistry and Biochemistry from Iowa State Univ. and a doctorate from Cornell Univ. with Dr. Robert Wasserman, a leading researcher of vitamin D and calcium nutrition and member of the National Academy of Science.  Post-doctoral work was done at Harvard Med. School and Univ. N. Carolina - Chapel Hill.  She has held faculty positions at Duke University Med. Ctr. and N. Carolina State Univ. and now Univ. of LA-Monroe, College of Pharmacy.  She has authored ~75 peer-reviewed journal articles and book chapters.  She is a long-standing member of Society of Toxicology and American Association for Cancer Research.  Her greatest moments in her profession are watching the advancement of her students and contributing information of use for protecting the public from chemical toxicity.

Licensure & Certification

Fellow, Academy of Toxicological Sciences. (2019 - Present)

Research Interests

Dr. Meyer's current research interests are:  1) identifying the Echinacea active principle(s) mediating stimulation of bone marrow progenitors of myeloid lineage, 2) myelosuppression by environmental chemicals and their environmental degradation products and 3) use of multivariate statistical methods and analytical chemistry (i.e., chemometrics) to identify which constituent of crude oil is responsible for a particular toxicity of the unfractionated mixture. 

Recent Publications

Qusa, M., El Sayed, K., Meyer, S. A., et al., . (2020). The Olive Oil Lignan (+)-Acetoxypinoresinol Peripheral Motor and Neuronal Protection against the Tremorgenic Mycotoxin Penitrem A Toxicity via STAT1 Pathway. ACS Chem Neurosci.
Shrestha, L., Jois, S. D., Meyer, S. A., et al., . (2020). In vivo studies of a peptidomimetic that targets EGFR dimerization in NSCLC. (pp. 5982-5999). J Cancer.
Siddique, A. B., El Sayed, K., King, J. A., Meyer, S. A., et al, . (2020). Safety Evaluations of Single Dose of the Olive Secoiridoid S-(-)-Oleocanthal in Swiss Albino Mice. (pp. 314). Nutrients.
Siddique, A. B., El Sayed, K., Meyer, S. A. (2020). (-)-Oleocanthal as a Dual c-MET-COX2 Inhibitor for the Control of Lung Cancer (pp. 1749). Nutrients. 2020 Jun 11;12(6):1749.
Siddique, A. B., El Sayed, K., Meyer, S. A., et al., . (2019). (-)-Oleocanthal Prevents Breast Cancer Recurrence After Primary Tumor Surgical Excision and Neoadjuvant Targeted Therapy in Orthotopic Nude Mouse Models. Cancers (Basel).
Siddique, A. B., Meyer, S. A., El Sayed, K., et. al., . (2019). Combinatorial synergistic treatment with dual HER2/EGFR inhibitor lapatinib and the olive-based oleocanthal against HER2-dependent breast cancer in vitro and in vivo. (pp. E412). Nutrients.
Kulkarni, S. R., Wallace, A. D., Meyer, S. A., Slitt, A. L. (2018). Molecular mechanisms of hepatotoxicity. IN: Molecular and Biochemical Toxicology, 5th Ed. (Hodgson, E., R. Smart, eds.). NY: John Wiley & Sons.
Meyer, S. A., Wetmore, B. A. (2018). Cellular Techniques. IN: Molecular and Biochemical Toxicology, 5th Ed. (Hodgson, E., R. Smart, eds.). NY: John Wiley & Sons.
Hodgson, E., Meyer, S. A. (2016). Pesticides and Hepatotoxicity IN: Comprehensive Toxicology, 3rd ed., (McQueen, C., ed) Vol. 9, Hepatic Toxicology, (Roth, R. and Ganey, P., vol. eds.). Elsevier.
Ramasahayam, S., Jaligama, S., Atwa, S., Salley, J. T., Thongby, M., Blaylock, B., Meyer, S. A. (2017). Megakaryocyte expansion and macrophage infiltration with MNX, N-nitroso environmental degradation product of munitions compound RDX (hexahydro-1, 3, 5-trinitro-1, 3, 5-triazine), in bone marrow of subchronically exposed rats (pp. 913-21). J. Appl. Toxicol..
Hodgson, E., Meyer, S. A. (2018). 2.22 Metabolism and Hepatotoxicity of Pesticides (pp. 538–574). Reference Module in Biomedical Research.
Deng, Y., Ai, J., Wilbanks, M., Meyer, S., Perkins, E. (2014). MicroRNA and messenger RNA profiling reveals new biomarkers and mechanisms for RDX induced neurotoxicity (pp. 12 p.). BMC Genomics.
Jaligama, S., Kale, V. M., Wilbanks, M. S., Perkins, E. J., Meyer, S. A. (2013). Delayed myelosuppression with acute exposure to hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and environmental degradation product hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX) in rats. (pp. 443-51). Toxicol Appl Pharmacol.
Akl, M. R., Meyer, S. A., El Sayed, K. A. (2014). Dichlorobenzoyl Sipholenol A Inhibits Breast Cancer Cell Growth and Motility in vitro and in vivo through Suppression of Brk and FAK Signaling (pp. 2282-304). Marine Drugs.
Sallam, A., Meyer, S. A., El Sayed, K. A. (2014). Marine Natural Products-Inspired Phenylmethylene Hydantoins with Potent in Vitro and in Vivo Antitumor Activities via Suppression of Brk and FAK Signaling (pp. 5295-303). Org. & Biomol. Chem..
Wilbanks, M. S., Meyer, S. A. (2014). Validation of a genomics-based hypothetical adverse outcome: 2,4-dinitrotoluene perturbs PPAR signaling thus impairing energy metabolism and exercise endurance. (pp. 44-58). Toxicological Sciences.
Bhinge, K., Meyer, S., Liu, Y. (2012). Bhinge, K., V. Gupta, S. Hosain. S.D. Satyanarayanajois S.A.Meyer, B. Blaylock. Q.J. Zhang, and Y.Y. Liu. The opposite effects of doxorubicin on bone marrow stem cells versus breast cancer stem cells depend on glucosylceramide synthase. (pp. 1770-1778). Int. J. Biochem. Cell Biol..
Meyer, S., Ramasahayam, S. (2014). Echinacea. Elsevier.
Hodgson, E., LeBlanc, G. A., Meyer, S., Smart, R. C. Introduction to Biochemical and Molecular Methods in Toxicology IN: A Textbook of Modern Toxicology, 4th ed. (pp. 15-27). Hoboken, NJ: John Wiley & Sons.
Meyer, S. Overview of cellular techniques in toxicology. IN: Molecular and Biochemical Toxicology, 4th Ed. NY: John Wiley & Sons.
Deng, Y., Meyer, S., Perkins, E. J. (2011). Analysis of common and specific mechanisms of liver function affected by nitrotoluene compounds (pp. e14662). PLoS One.
Ramasaham, S., El Sayed, K., Meyer, S. (2011). Effects of chemically characterized fractions from aerial parts of Echinacea purpurea and angustifolia on myelopoiesis in rats (pp. 1883-9). Planta Medica.
Chowbina, S. Y., Meyer, S., Perkins, E. J. (2010). A new approach to construct pathway connected networks and its application in dose responsive gene expression profiles of rat liver regulated by 2,4DNT (pp. S4-11). BMC Genomics.
Meyer, S., Blake, B. L. (2010). Forensic and Clinical Toxicology IN: A Textbook of Modern Toxicology, 4th ed. (pp. 457-473). NY: John Wiley & Sons, Inc.
Wallace, A. D., Meyer, S. (2010). Hepatotoxicity IN: A Textbook of Modern Toxicology, 4th ed. (pp. 275-290). NY: John Wiley & Sons, Inc.
Wallace, A. D., Meyer, S. (2010). Hepatotoxicity IN: Molecular and Biochemical Toxicology, 4th Ed. (pp. 671-692). NY: John Wiley & Sons.
Sallam, A., Ramasahayam, S., Meyer, S., El Sayed, K. (2010). Design, synthesis, and biological evaluation of dibromotyrosine analogues inspired by marine natural products as inhibitors of human prostate cancer proliferation, invasion, and migration (pp. 7446–7457). New York: Elsevier.
Hodgson, E., Meyer, S. (2010). Pesticides IN: Comprehensive Toxicology, 2nd ed., Vol. 10, Hepatic Toxicology. Elsevier.
Kale, V. J., Meyer, S. (2008). Comparative cytotoxicity of chloroacetanilide herbicides alachlor, acetochlor and metolachlor in rat and cryopreserved human hepatocytes (pp. 41-50). J. Biochem. Mol. Toxicol.
Miranda, S. R., Meyer, S. (2007). Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. . , 2007 (pp. 871-877). Food Chem. Toxicol.
Perkins, E. J., Meyer, S. (2006). Comparison of gene expression effects in liver tissue and primary hepatocyte cell cultures after exposure to hexahydro-1,3,5-trinitro-1,3,5-triazine (pp. S22-28). BMC Bioinformatics 7(Suppl 4):S22-28, 2006..
Meyer, S. A. (2005). Up-and-down procedure (UDP) determination of acute toxicity of nitroso degradation products of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (pp. 427-434). J. Appl. Toxicol..
Meyer, S., Marchand, A., Hight, J., Roberts, G. H., Escalon, L., Inouye, L., MacMillan, D. (2005). Up-and-dpwn procedure (UDP) determinations of acute oral toxicity of nitroso degradation products of hexahydro 1,3,5-trinitro-1,3,5-triazine (RDX). Journal of Applied Toxicology.
Dalton, S. R., Miller, R. T., Meyer, S. A. (2003). Herbicide metolachlor induces liver cytochrome P450s 2B1/2 and 3A1/2, but not thyroxine-uridine dinucleotide phosphate glucuronosyltransferase and associated thyroid gland activation (pp. 287-295). Int. J. Toxicol..
Dalton, S. R., Meyer, S. A. (2000). EGF receptors of hepatocytes from rats treated with phenobarbital are sensitized to down-regulation by phenobarbital in culture (pp. 115-126). Toxicol. Appl Pharmacol..

Research Grants

Meyer, S. A. (Co-Principal), Jois, S. (Principal), "R01: Grafted peptides as therapeutic agents for suppressing inflammation: molecular mechanism and biopharmaceutical properties" (Funded), Sponsored By NIH, The University of Louisiana at Monroe, $30K (1.5 mo/yr). (January 1 2021 - December 31 2025).
Meyer, S. A. (Supporting), El Sayed, K. (Principal), "" (Funded), Sponsored By NIH/STTR, The University of Louisiana at Monroe, $. (2021 - 2022).
Meyer, S. A. (Principal), Barnett, H. (Supporting), Gentry, R. (Supporting), "Assessment of Risk of Human Health Effects of Specific Crude Oil Predicted from Compositional Profile" (Not Funded), Sponsored By Natl. Acad. Sci., Gulf Research Program, External to The University of Louisiana at Monroe, $719640. (December 2017 - November 2020).
Meyer, S. A. (Principal), El-Giar, E. (Co-Principal), "Ultra-high performance liquid chromatography capability to enhance research and training among ULM toxicology, chemistry and pharmacology" (Not Funded), Sponsored By LA BoR, External to The University of Louisiana at Monroe, $91,645. (2018 - 2019).
Meyer, S. A. (Principal), "Dietary Supplement Echinacea Rescue of Chemical Myelosuppression" (Not Funded), Sponsored By NIH, External to The University of Louisiana at Monroe, $. (April 2015 - March 2018).
Meyer, S. (Co-Principal), "Optimization of Echinacea spp. medicinal activity utilizing source-identified germplasm curated at the North Central Region Plant Introduction Station" (Funded), Sponsored By US Dept Agriculture (CRIS Proj#: 3625-21000-05 -00D), External to The University of Louisiana at Monroe, $12000. (September 30 2013 - August 31 2015).
Meyer, S. (Principal), El Sayed, K. (Co-Principal), Kemp, R. (Co-Principal), Widrlechner, M. (Supporting), "Dietary Supplement Echinacea Rescue of Chemical Myelosuppression" (Not Funded), Sponsored By NIH/NIEHS 1R21ES021278-01, External to The University of Louisiana at Monroe, $426000. (April 2012 - April 2014).
Meyer, S. (Principal), "Effect of Exposure to the Nitroaromatic 2,4DNT on Energy Metabolism and Exercise Endurance in Mice" (Funded), Sponsored By Dept of Defense, US Army Corps of Engineers, External to The University of Louisiana at Monroe, $38200. (September 1 2011 - March 31 2012).

Awards & Honors

April 2018 Excellence in Teaching Award.

March 2018 Grant Reviewer of Joint Global Health Trials.

July 2017 Study Section, ZRG1 DKUS J, Physiological & Pathological Sciences.

March 2017 Study Section, ZRG1 DKUS J, Physiological & Pathological Sciences.

July 2014 Member, Scientific Advisory Committee.

June 2014 Fellow.

2014 Study Section, ZRG1 DKUS-N; Digestive Sciences.

2008 Study Section PHTBI-4; Traumatic Brain Injury/PTSD; Clinical Trials.

July 2008 2011 Member, Scientific Advisory Committee on Alternative Toxicological Methods.

1984 NIH/NINCDS Postdoctoral Fellowship (F32).

1977 Sigma Xi.

1971 Phi Kappa Phi.

Courses Taught

PHAR 5050BIOCHEMICAL TOXICOLOGY, 12 course(s)

PHAR 5052SEMINAR, 13 course(s)

PHAR 5064Pharmacogenetics, 1 course(s)

PHAR 5081ADVANCED TOXICOLOGY, 11 course(s)

PHAR 5082ADVANCED TOXICOLOGY LABORATORY, 11 course(s)

PHAR 5090METH/PRINCIPLES OF TOXICOLOGY, 10 course(s)

PHRD 4027PRINCIPLES OF DRUG ACTION II, 11 course(s)

PHRD 5057PHARMACOGENETICS, 3 course(s)

TOXI 1001Toxicology & Environment, 2 course(s)

TOXI 4001GENERAL LAB TECHNIQUES, 15 course(s)

TOXI 4011GENERAL TOXICOLOGY, 15 course(s)

TOXI 4013Gen Tox Lab, 3 course(s)

TOXI 4024CLINICAL TOXICOLOGY, 14 course(s)

TOXI 4091SEMINAR, 7 course(s)