faculty portrait if available
Karen Briski
Professor
School Basic Pharm & Toxicol Sci
PHAR 356
318-342-3283
ULM logo

Karen P Briski, PhD
Professor, Pharmacy
Head, Department of Basic Pharmaceutical Sciences

Education

Ph D

1981, Anatomy
The University of Michigan

MS

1977, Anatomy
The University of Michigan

BS

1975, Biology
Albright College

faculty feature photo

Biographical Sketch

I, Karen P. Briski, Ph.D., am an academic researcher and administrator with credentials and expertise in the neuroscience disciplines of reproductive neuroendocrinology and brain metabolic monitoring.  I am Professor of Pharmacology and Neuroanatomy, and Head, Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe (ULM).  I completed my doctoral degree education the Department of Anatomy, University of Michigan Medical School, and postdoctoral training in the Reproductive Neuroendocrine Laboratory, Department of Physiology, Michigan State University, under the tutelage of Dr. Joseph Meites, Ph.D., Professor of Physiology.  My department provides unique research and instructional expertise in the interrelated disciplines of pharmacology, pharmaceutics, and medicinal/natural products chemistry to the state, region, and nation at large. It occupies a unique niche in ULM and the University of Louisiana System, and is essential to the educational, research, and service missions of these institutions.  As Department Head, I nurture vital goals and objectives that aim to improve and advance the unit’s research culture and perspective, serve faculty needs, and guide it to a leadership role within the ULM academic community. Important aspects of my tenure in that role include recruitment and retention of talented and adept faculty, acquisition of a research infrastructure that supports cutting-edge research activities, identification of funding for inter-disciplinary research initiatives that exploit the department’s numerous strengths, and the pursuit of a state-wide and regional reputation for excellence in research in the pharmaceutical sciences.  Those efforts are facilitated by the development and implementation of a long-term strategic plan that outlines the department’s current situation, its aspirations, and as viable mechanisms for attaining the goals it has established for itself.  Faculty development has been a major positive element in the department’s growth. Under my direction, a mechanism for mentoring of junior faculty by senior members on issues relating to research and teaching was established, along with a formal third-year review process intended to provide constructive feedback to assistant professors prior to the tenure/promotion review process.  I have worked to increase individual and team-based research productivity and establish a critical mass of established, extramurally-funded research programs, through creative strategies, including informal departmental research forums and emphasis on cross-disciplinary communication and brainstorming.

Over my career, my research has been/is funded as Principal Investigator by the National Institutes of Health, National Science Foundation, Children’s Brain Tumor Foundation, American Diabetes Association, Juvenile Diabetes Research Foundation, and Louisiana Board of Regent Support Fund. I have published more than 100 peer-revised manuscripts on neuroscience research.  I supervise, train, and mentor doctoral students, and lecture on a number of topics in the School’s professional Doctor of Pharmacy curriculum.  I strive to expose my trainees to multi-faceted investigative approachs that integrate complimentary neuroanatomical, physiological, molecular biological, and pharmacological techniques to address pivotal hypothesis-driven research on complications of metabolic disorders.  My laboratory is currently engaged in developing novel methods for high-resolution characterization of activated, multi-neuron brain pathways.  Our functional mapping strategy involves the unique pairing of micro-particle induced X-ray emission (µPIXE) spectrometry with compatible state-of-the-art laser-catapult microdissection/molecular biological analyses as a means to identify brain circuity components by neuroanatomical location, neurochemical identity, and receptivity to energetic and endocrine cues. 1) Energy balance is a key determinant of reproductive success in females. Fertility in women and other mammalian species declines when energy supply cannot meet metabolic demands.  The ESHRE Workshop Group on Nutrition and Reproduction in Women notes that energy deficiency is highly correlated with reduced frequency or cessation of ovulation. Our technology development supports funded work aimed at characterizing neural networks that repress reproductive neuroendocrine function in the brain in response to metabolic deficiency.  2) Neuron-glial cell metabolic coupling involves nerve cell import of fuel substrates for high demand aerobic respiration.  Glial glycogen is a critical energy fuel reserve as enhanced astrocyte glycogen mass alleviates neuron dysfunction and demise during hypoglycemia.  As our studies show that estrogen enhances glycogen metabolism during hypoglycemia, our current aims to identify cellular and molecular mechanisms of hormonal regulation of astrocyte glycogen mass, as we expect that such knowledge can be leveraged to develop neuro-protective therapies against hypoglycemic brain injury.  3) Eating behavior is a complex interplay of physiological, psychological, social, and genetic factors that influence meal timing, quantity of food intake, and food preference.  The ideal circumstance of unfettered ability to eat-at-will, in response to the above drives, can be impractical in reality; indeed, short-term suspension of food intake, planned or unplanned, is often unavoidable and unpredictable in modern life.  Reduced eating frequency, e.g. meal omission, in human subjects negatively affects appetite control.  We have developed a novel experimental model for transient disruption of fuel acquisition, leading to discovery that estradiol mitigates acute and post-acute adverse effects of interrupted feeding.  Ongoing work aims to identify potential targets for therapeutic mitigation of rebound food consumption and amplified diversion of fuel to storage.

Research Interests

Our laboratory is engaged in the development of novel methodology for high-resolution characterization of activated, multi-neuron brain pathways.  Our functional mapping strategy involves the unique pairing of micro-particle induced X-ray emission (µPIXE) spectrometry with compatible state-of-the-art laser-catapult microdissection/molecular biological analyses as a means to identify brain circuity components by neuroanatomical location, neurochemical identity, and receptivity to energetic and endocrine cues.

i.   Energy balance is a key determinant of reproductive success in females.  Fertility in women and other mammalian species declines when energy supply cannot meet metabolic demands.  Indeed, the ESHRE Workshop Group on Nutrition and Reproduction in Women [2006] notes that energy deficiency is highly correlated with reduced frequency or cessation of ovulation. Our technology development supports funded work that seeks to characterize the neural network that represses reproductive neuroendocrine function in the brain in response to metabolic deficiency. 

ii.   Proposed research will this combinatory tool to investigate the premise that Roux-en-Y gastric bypass surgery diminishes accumulation of important trace elements in the brain, and that consequent decline in micro-mineral loading of critical oxidative stress/energy metabolic enzymes impairs brain defenses against bio-energetic insults including stroke. 

iii.   Neuron-glial cell metabolic coupling involves nerve cell import of fuel substrates for high demand aerobic respiration.  Glial glycogen is a critical energy fuel reserve as enhanced astrocyte glycogen mass alleviates neuron dysfunction and demise during hypoglycemia.  As our studies show that estrogen enhances glycogen metabolism during hypoglycemia, current work by our group seeks to identify cellular and molecular mechanisms of hormonal regulation of astrocyte glycogen mass, as we expect that such knowledge can be leveraged to develop neuro-protective therapies against hypoglycemic brain injury. 

iv.  Eating behavior is a complex interplay of physiological, psychological, social, and genetic factors that influence meal timing, quantity of food intake, and food preference.  The ideal circumstance of unfettered ability to eat-at-will, in response to the above drives, can be impractical in reality; indeed, short-term suspension of food intake, planned or unplanned, is often unavoidable and unpredictable in modern life.  Reduced eating frequency, e.g. meal omission, in human subjects negatively affects appetite control. We developed a novel experimental model for transient disruption of fuel acquisition developed by our group, leading to discovery that estradiol mitigates acute and post-acute adverse effects of interrupted feeding.  We aim to identify potential targets for therapeutic mitigation of rebound food consumption and amplified diversion of fuel to storage.

 

Recent Publications

Bheemanapally, K., Ibrahim, M. M., Briski, K. P. (2020). Quality by design optimization of ultra-high-performance liquid chromatography-electrospray ionization-mass spectrometry for high-neuroanatomical resolution quantification of brain estradiol concentrations. Journal of Pharmaceutical and Biomedical Analysis.
Ibrahim, M. M., Bheemanapally, K., Sylvester, P. W., Briski, K. P. (2020). Sex differences in glucoprivic regulation of glycogen metabolism in hypothalamic primary astrocyte cultures: role of estrogen receptor signaling. Molecular Cellular Endocrinology.
Ibrahim, M. M., Uddin, M. M., Bheemanapally, K., Briski, K. P. (2020). Sex-dimorphic aromatase regulation of ventromedial hypothalamic nucleus glycogen content in euglycemic and insulin-induced hypoglycemic rats. Neuroscience Letters.
Briski, K. P., Ali, M., Napit, P. R. (2020). Sex-specific acclimation of A2 noradrenergic neuron dopamine-β-hydroxylase and estrogen receptor variant protein and 5’-AMP-activated protein kinase reactivity to recurring hypoglycemia in the rat. Journal of Chemical Neuroanatomy.
Uddin, M. M., Ibrahim, M. M., Briski, K. P. (2020). Sex-specific moderate hypoglycemia preconditioning effects on hippocampal CA1 neuron bio-energetic and anti-oxidative function. (pp. 39-50). Molecular Cellular Biochemistry.
Alshamrani, A., Bheemanapally, K., Ibrahim, M. M., Briski, K. P. (2020). Impact of caudal hindbrain glycogen metabolism on A2 noradrenergic neuron AMPK activation and ventromedial hypothalamic nucleus norepinephrine activity and glucoregulatory neurotransmitter marker protein expression. Neuropeptides.
Mahmood, A., Uddin, M. M., Ibrahim, M. M., Briski, K. P. (2020). Norepinephrine regulation of ventromedial hypothalamic nucleus metabolic-sensory neuron 5’-AMP-activated protein kinase activity: impact of estradiol. International Journal of Molecular Sciences.
Bheemanapally, K., Ibrahim, M. M., Briski, K. P. (2020). Optimization of ultra-high performance liquid chromatography-electrospray ionization-mass spectrometry detection of glutamine-FMOC ad-hoc derivative by central composite design. Scientific Reports.
Bheemanapally, K., Ibrahim, M. M., Briski, K. P. (2020). High performance liquid chromatography-electrospray ionization mass spectrometric (LC-ESI-MS) methodology for analysis of amino acid energy substrates in microwave-fixed microdissected brain tissue. Journal of Pharmaceutical and Biomedical Analysis.
Briski, K. P., Bheemanapally, K., Ibrahim, M. M. (2020). Effects of acute versus recurrent insulin-induced hypoglycemia on ventromedial hypothalamic nucleus metabolic-sensory neuron AMPK activity: Impact of alpha1-adrenergic receptor signaling. (pp. 41-50). Brain Research Bulletin.
Ibrahim, M. M., Bheemanapally, K., Sylvester, P. W., Briski, K. P. (2020). Sex-specific estrogen regulation of hypothalamic astrocyte estrogen receptor expression and glycogen metabolism in rats. Molecular Cellular Endocrinology.
Mahmood, A., Napit, P. R., Ali, M., Briski, K. P. (2020). Estrogen receptor involvement in noradrenergic regulation of ventromedial hypothalamic nucleus glucoregulatory neurotransmitter and stimulus-specific glycogen phosphorylase enzyme isoform expression. ASN Neuro.
Ibrahim, M. M., Bheemanapally, K., Alhamami, H. N., Briski, K. P. (2020). (pp. 647-658). Journal of Molecular Neuroscience.
Briski, K. P., Mandal, S. K. (2020). Hindbrain metabolic deficiency regulates ventromedial hypothalamic nucleus glycogen metabolism and glucose-regulatory signaling (pp. 57-65). Acta Neurobiologica Experimentalis.
Bheemanapally, K., Ibrahim, M. M., Briski, K. P. (2020). Combinatory high-resolution microdissection/ultra performance liquid chromatographic-mass spectrometry approach for small tissue volume analysis of rat brain glycogen. Journal of Pharmaceutical and Biomedical Analysis.
Briski, K. P., Mandal, S. K. (2019). Hindbrain lactoprivic regulation of hypothalamic neuron transactivation and glucoregulatory neurotransmitter expression: Impact of antecedent insulin-induced hypoglycemia. Neuropeptides.
Uddin, M. M., Mahmood, A., Ibrahim, M. M., Briski, K. P. (2019). Sex dimorphic estrogen receptor regulation of ventromedial hypothalamic nucleus glucoregulatory neuron adrenergic receptor expression in hypoglycemic male and female rats. Brain Research.
Napit, P. R., Ali, M., Shakya, M., Mandal, S. K., Bheemanapally, K., Mahmood, A., Ibrahim, M. M., Briski, K. P. (2019). Hindbrain estrogen receptor regulation of counter-regulatory hormone secretion and ventromedial hypothalamic nucleus glycogen content and glucoregulatory transmitter signaling in hypoglycemic female rats (pp. 211-221). Neuroscience.
Dronamraju, V. (2019). γ-Tocotrienol suppression of the Warburg effect Is mediated by AMPK activation in human breast cancer cells. (pp. 1-15). Nutrition and Cancer.
Ali, M., Napit, P. R., Mahmood, A., Bheemanapally, K., Alhamami, H. N., Uddin, M. M., Ibrahim, M. M., Briski, K. P. (2019). Hindbrain estrogen receptor regulation of ventromedial hypothalamic glycogen metabolism and glucoregulatory transmitter expression in the hypoglycemic male rat. (pp. 253-260). Neuroscience.
Mahmood, A., Bheemanapally, K., Mandal, S. K., Ibrahim, M. M., Briski, K. P. (2019). Norepinephrine control of ventromedial hypothalamic nucleus glucoregulatory neurotransmitter expression in the female rat: role monocarboxylate transporter function (pp. 51-58). Molecular Cellular Neuroscience.
Ibrahim, M. M., Alhamami, H. N., Briski, K. P. (2019). Norepinephrine regulation of ventromedial hypothalamic nucleus metabolic transmitter biomarker and astrocyte enzyme and receptor expression: impact of 5’-AMP-activated protein kinase (pp. 48-57). Brain Research.
Mandal, S. K., Briski, K. P. (2018). Hindbrain dorsal vagal complex AMPK controls hypothalamic AMPK activation and metabolic neurotransmitter protein expression and counter-regulatory hormone secretion in the hypoglycemic male rat (pp. 171-179). Brain Research Bulletin.
Mahmood, A., Uddin, M. M., Mandal, S. K., Ibrahim, M. M., Alhamami, H. N., Briski, K. P. (2018). Sex differences in forebrain estrogen receptor regulation of hypoglycemic patterns of counter-regulatory hormone secretion and ventromedial hypothalamic nucleus gluco-regulatory neurotransmitter and astrocyte glycogen metabolic enzyme expression (pp. 65-74). Neuropeptides.
Briski, K. P., Shakya, M. (2018). Mu opioid receptor regulation of gonadotropin-releasing hormone-luteinizing hormone axis during short-term food deprivation: role of alpha1-adrenergic signaling. (pp. 363-370). Neuroendocrine Letters.
Mandal, S. K., Shrestha, P. K., Alenazi, F., Shakya, M., Alhamami, H. N., Briski, K. P. (2018). Effects of estradiol on lactoprivic signaling of the hindbrain upon the contraregulatory hormonal response and metabolic neuropeptide synthesis in hypoglycemic female rats (pp. 37-46). Neuropeptides.
Shakya, M., Alhamami, H. N., Briski, K. P. (2018). Hindbrain 5’-monophosphate-activated protein kinase mediates short-term food deprivation inhibition of the gonadotropin-releasing hormone-luteinizing hormone axis: role of nitric oxide (pp. 46-69). Neuroscience.
Alhamami, H. N., Uddin, M. M., Mahmood, A., Briski, K. P. Lateral but not medial hypothalamic AMPK activation occurs at the hypoglycemic nadir in insulin-injected male rats: Impact of caudal dorsomedial hindbrain catecholamine signaling. (pp. 103-114). Neuroscience.
Briski, K. P., Alhamami, H. N., Alshamrani, A., Mandal, S. K., Shakya, M., Ibrahim, M. M. (2017). . Sex differences and role of estradiol in hypoglycemia-associated counter-regulation. (pp. 359-383). Adv. Exp. Med. Biol..
Fakhruddin, S., Alanazi, W. A., Alhamami, H. N., Briski, K. P., Jackson, K. E. (2017). Hyperglycemia induced by chronic I.P. and oral glucose loading leads to hypertension through increased Na+-retention in proximal tubule (pp. 236-249). Exp. Physiol.
Alhamami, H. N., Alshamrani, A., Briski, K. P. (2018). Inhibition of the glycogen phosphorylase stimulates ventromedial hypothalamic nucleus 5’-adenosine monophosphate-activated protein kinase activity and neuronal nitric oxide synthase protein expression in male rats. Physiological Reports.
Shakya, M., Briski, K. P. (2017). Deferred feeding in the wake of short-term suspension of food intake differs in the presence of estrous cycle peak- versus nadir levels of estradiol. (pp. 475-484). Endocrinology and Metabolism.
Mandal, S. K., Shrestha, P. K., Alenazi, F., Shakya, M., Alhamami, H. N., Briski, K. P. Role of hindbrain adenosine 5’-monophosphate-activated protein kinase (AMPK) in hypothalamic AMPK and metabolic neuropeptide adaptation to recurring insulin-induced hypoglycemia in the male rat (pp. 25-35). Neuropeptides.
Tamrakar, P., Briski, K. P. (2017). Impact of recurrent hypoglycemic stress on metabolic signaling in dorsal vagal complex neurons: modulation by estradiol (pp. 31-44). Acta Neurobiologica Experimentalis.
Briski, K. P., Alenazi, F. S., Shakya, M., Sylvester, P. W. (2017). Estradiol regulates hindbrain A2 noradrenergic neuron adenosine 5'-monophosphate-activated protein kinase (AMPK) activation, upstream kinase/phosphatase protein expression, and receptivity to hormone and fuel reporters of short-term food deprivation in the ovariectomized female rat. (pp. 1427-1437). Journal of Neuroscience Research.
Shrestha, P. K., Briski, K. P. (2016). Hindbrain estrogen receptor-beta antagonism normalizes reproductive and counter-regulatory hormone secretion in hypoglycemic steroid-primed ovariectomized female rats (pp. 62-71). Neuroscience.
Alawin, O., Ahmed, R., Ibrahim, B. A., Briski, K. P., Sylvester, P. W. (2016). Antiproliferative effects of gamma-tocotrienol are associated with lipid raft disruption in HER2-positive human breast cancer cells. (pp. 266-277). Journal Nutritional Biochemistry.
Alenazi, F. S., Ibrahim, B. A., Briski, K. P. (2016). Role of estradiol in intrinsic hindbrain AMPK regulation of hypothalamic AMPK, metabolic neuropeptide, and norepinephrine activity and food intake in the female rat. (pp. 35-46). Neuroscience.
Shrestha, P. K., Briski, K. P. (2015). Hindbrain lactate regulates preoptic gonadotropin-releasing hormone (GnRH) neuron GnRH-1 protein but not AMPK responses to hypoglycemia in the steroid-primed ovariectomized female rat. (pp. 467-474). Neuroscience.
Alenazi, F. S., Ibrahim, B. A., Briski, K. P. (2015). Estradiol regulates dorsal vagal complex signal transduction pathway transcriptional reactivity to the AMPK activator 5-aminoazole-4-carboxamide-riboside (AICAR) (pp. 907-916). Journal of Molecular Neuroscience.
Alenazi, F. S., Ibrahim, B. A., Briski, K. P. (2015). Re-purposing of histological tissue sections for corroborative western blot analysis of hypothalamic metabolic neuropeptide expression following delineation of transactivated structures by Fos immuno-mapping. (pp. 29-33). Neuropeptides.
Tamrakar, P., Shrestha, P. K., Briski, K. P. (2015). Dorsomedial hindbrain catecholamine regulation of hypothalamic astrocyte glycogen metabolic enzyme protein expression: Impact of estradiol. (pp. 34-45). Neuroscience.
Tamrakar, P., Briski, K. P. (2015). Estradiol regulates hypothalamic astrocyte glycogen metabolic adenosine 5'-monophosphate-activated protein kinase activation by hypoglycemia: role of hindbrain catecholamine signaling. (pp. 47-52). Brain Research Bulletin.
Ibrahim, B. A., Alenazi, F. S., Briski, K. P. (2015). Energy status determines hindbrain signal transduction pathway transcriptional reactivity to AMPK in the estradiol-treated ovariectomized female rat. (pp. 888-889). Neuroscience.
Tamrakar, P., Shrestha, P. K., Briski, K. P. (2014). Sex-specific basal and hypoglycemic patterns of in vivo caudal dorsal vagal complex astrocyte glycogen metabolic enzyme protein expression (pp. 90-98). Brain Research.
Alenazi, F. S., Ibrahim, B. A., Briski, K. P. (2014). Estradiol regulates effects of hindbrain activator 5-aminoimidazole-4-carboximide-riboside administration on hypothalamic adenosine 5'-monophosphate-activated protein kinase activity and metabolic neurotransmitter mRNA and protein expression. (pp. 651-659). Journal of Neuroscience Research.
Shrestha, P. K., Tamrakar, P., Ibrahim, B. A., Briski, K. P. (2014). Hindbrain medulla catecholaminergic cell group involvement in lactate-sensitive hypoglycemia-associated patterns of hypothalamic norepinephrine and epinephrine activity. (pp. 20-30). Neuroscience.
Ibrahim, B. A., Briski, K. P. (2014). Role of dorsal vagal complex A2 noradrenergic neurons in hindbrain glucoprivic inhibition of the luteinizing hormone surge in the steroid-primed ovariectomized female rat: Effects of 5-thioglucose on A2 functional biomarker and AMPK activity. (pp. 199-214). Neuroscience.
Briski, K. P., Ibrahim, B. A., Tamrakar, P. (2014). Energy metabolism and hindbrain AMPK: regulation by estradiol (pp. 129-136). Horm. Mol. Biol. Clin. Invest.
Cherian, A. K., Briski, K. P. (2012). A2 noradrenergic nerve cell metabolic transducer and nutrient transporter adaptation to hypoglycemia: Impact of estrogen (pp. 1347-1358). Journal of Neuroscience Research.
Vavaiya, K. V., Briski, K. P. (2008). Effects of caudal fourth ventricular lactate infusion on hypoglycemia-associated MCT2, GLUT3, GLUT4, GCK, and sulfonylurea receptor-1 gene expression in the ovariectomized female rat LHA and VMH. (pp. 121-129). Journal of Molecular Neuroscience.
Tamrakar, P., Ibrahim, B. A., Gujar, A. D., Briski, K. P. (2015). Estrogen regulates energy metabolic pathway and upstream AMPK kinase and phosphatase enzyme expression in dorsal vagal complex metabolo-sensory neurons during glucostasis and hypoglycemia (pp. 321-332). Journal of Neuroscience Research.
Genabai, N. K., Briski, K. P. (2010). Adaptation of arcuate nucleus insulin receptor, estrogen receptor-alpha, estrogen receptor-beta, and type II glucocorticoid receptor gene profiles to intermediate insulin-induced hypoglycemia in estrogen-treated ovariectomized female rats. (pp. 304-309). Journal of Molecular Neuroscience.
Briski, K. P., Nedungadi, T. P. (2009). Adaptation of feeding and counter-regulatory hormone responses to intermediate insulin-induced hypoglycemia in the ovariectomised female rat: effects of oestradiol. (pp. 578-585). Journal of Neuroendocrinology.
Genabai, N. K., Vavaiya, K. V., Briski, K. P. (2009). Adaptation of glucokinase gene expression in the rat dorsal vagal complex in a model for recurrent intermediate insulin-induced hypoglycemia: impact of gender. (pp. 80-86). Journal of Molecular Neuroscience.
Ibrahim, B. A., Tamrakar, P., Gujar, A. D., Briski, K. P. (2013). Caudal fourth ventricular admininstration of the AMPK activator 5-aminoimidazole-4-carboximide-riboside regulates glucose amd counterregulatory hormone profiles, dorsal vagal complex metabolo-sensory neuron function, and hypothalamic Fos expression (pp. 1226-1238). Journal of Neuroscience Research.
Singh, S., Briski, K. P. (2004). Caudal hindbrain glucoprivation enhances GABA release in discrete septopreoptic structures in the steroid-primed ovariectomized rat brain: role of mu opioid receptors. (pp. 201-209). Neuroendocrinology.
Singh, S., Briski, K. P. (2005). Central GABAA, but not GABAB receptors mediate suppressive effects of caudal hindbrain glucoprivation on the LH surge in the steroid-primed, ovariectomized female rat. (pp. 407-412). Journal of Neuroendocrinology.
Kale, A. Y., Vavaiya, K. V., Briski, K. P. (2006). Effects of acute and chronic insulin-induced hypoglycemia on type II glucocorticoid receptor (GR) gene expression in characterized CNS metabolic loci in male rat brain. (pp. 240-244). Brain Research Bulletin.
Cherian, A. K., Briski, K. P. (2010). Effects of adrenalectomy on neuronal substrate fuel transporter and energy transducer gene expression in hypothalamic and hindbrain metabolic monitoring sites. (pp. 56-63). Neuroendocrinology.
Nedungadi, T. P., Briski, K. P. (2007). Effects of estradiol on acute and recurrent insulin-induced hypoglycemia-associated patterns of arcuate neuropeptide Y, propiomelanocortin, and cocaine- and amphetamine related-transcript gene expression in the ovariectomized female rat. (pp. 270-276). Neuroendocrinology.
Nedungadi, T. P., Goleman, W. L., Paranjape, S. A., Briski, K. P. (2006). Effects of estradiol on glycemic and CNS neuronal activational responses to recurrent insulin-induced hypoglycemia in the ovariectomized female rat. (pp. 235-243). Neuroendocrinology.
Briski, K. P., Nedungadi, T. P., Koshy Cherian, A. (2010). Effects of hypoglycaemia on neurotransmitter and receptor gene expression in arcuate neuropeptide Y/agouti-related peptide neurones. (pp. 599-607). Journal of Neuroendocrinology.
Nedungadi, T. P., Briski, K. P. (2010). Effects of intracerebroventricular administration of the Y1 receptor antagonist, 1229U91, on hyperphagic and glycemic responses to acute and chronic intermediate insulin-induced hypoglycemia (pp. 14-18). Regulatory Peptides.
Briski, K. P., Parihar, M. (2009). Effects of orchidectomy on adaptation of arcuate neuropeptide Y, proopiomelanocortin, and cocaine- and amphetamine related-transcript gene profiles to recurring insulin-induced hypoglycemia in the male rat. (pp. 585-591). Neuropeptides.
Sylvester, P., Shah, S. J., Haynie, D. T., Briski, K. P. (2005). Effects of ultra-wide band electromagnetic pulses on pre-neoplastic mammary epithelial cell proliferation. (pp. 153-163). Cell Proliferation.
Tamrakar, P., Ibrahim, B. A., Gujar, A. D., Briski, K. P. (2015). Estrogen regulates energy metabolic pathway and upstream AMPK kinase and phosphatase enzyme expression in dorsal vagal complex metabolo-sensory neurons during glucostasis and hypoglycemia. (pp. 321-332). Journal of Neuroscience Research.
Paranjape, S. A., Briski, K. P. (2006). Habituation of insulin-induced hypoglycemic transcriptional activation of lateral hypothalamic orexin-A-containing neurons to recurring exposure. (pp. 1-6). Regulatory Peptides.
Ibrahim, B. A., Briski, K. P. (2015). Deferred feeding and body weight responses to short-term interruption of fuel acquisition. (pp. 611-621). Hormone and Metabolic Research.
Gujar, A. D., Ibrahim, B. A., Tamrakar, P., Koshy Cherian, A., Briski, K. P. (2014). Hindbrain lactostasis regulates hindbrain and hypothalamic AMPK activity and hypothalamic metabolic neurotransmitter mRNA and protein responses to hypolycemia. American Journal of Physiology - Regul., Integr., and Comp. Physiol..
Gujar, A. D., Ibrahim, B. A., Tamrakar, P., Briski, K. P. (2013). Hypoglycemia differentially regulates hypothalamic glucoregulatory neurotransmitter gene and protein expression: role of caudal dorsomedial hindbrain catecholaminergic input. Neuropeptides.
Briski, K. P., Kale, A. Y., Vavaiya, K. V. (2009). Impact of recurring insulin-induced hypoglycemia on corticotropin-releasing hormone, oxytocin, vasopressin, and glucokinase gene expression in hypothalamic paraventricular nucleus: role of type II glucocorticoid receptors. (pp. 499-507). Experimental Brain Research.
Briski, K. P., Koshy Cherian, A., Genabai, N. K., Vavaiya, K. V. (2009). In situ coexpression of glucose and monocarboxylate transporter mRNAs in metabolic-sensitive dorsal vagal complex catecholaminergic neurons: transcriptional reactivity to insulin-induced hypoglycemia and caudal hindbrain glucose or lactate repletion during insulin-induced hypoglycemia (pp. 1152-1160). Neuroscience.
Briski, K. P., Patil, G. D. (2005). Induction of Fos immunoreactivity labeling in forebrain metabolic loci by caudal fourth ventricular administration of the monocarboxyate transporter inhibitor, α-cyano-4-hydroxycinnamic acid. (pp. 49-57). Neuroendocrinology.
Kale, A. Y., Paranjape, S. A., Briski, K. P. (2006). Intracerebroventricular administration of the nonsteroidal glucocorticoid receptor antagonist, CP4-72555, prevents exacerbation of hypoglycemia during repeated insulin administration. Neuroscience.
Patil, G. D., Briski, K. P. (2005). Lactate is a critical 'sensed' variable in caudal hindbrain monitoring of CNS metabolic stasis. (pp. R1777-R1786). American Journal of Physiology.
Cherian, A. K., Briski, K. P. (2011). Quantitative RT PCR and immunoblot analyses reveal acclimated A2 noradrenergic neuron substrate fuel transporter, glucokinase, phospho-AMPK, and dopamine-beta-hydroxylase responses to hypoglycemia. (pp. 1114-1124). Journal of Neuroscience Research.
Paranjape, S. A., Briski, K. P. (2005). Recurrent insulin-induced hypoglycemia causes site-specific patterns of habituation or amplification of CNS neuronal genomic activation (pp. 957-970). Neuroscience.
Paranjape, S. A., Vavaiya, K. V., Kale, A. Y., Briski, K. P. (2007). Role of dorsal vagal motor nucleus orexin-A receptor in glycemic responses to acute versus repeated insulin administration. (pp. 111-116). Neuropeptides.
Singh, S., Briski, K. P. (2004). Septopreoptic mu opioid receptor mediation of hindbrain glucoprivic inhibition of reproductive neuroendocrine function in the female rat. (pp. 5322-5331). Endocrinology.
Nedungadi, T. P., Genabai, N. K., Parihar, M., Briski, K. P. (2009). Sex differences in acclimation of hypothalamic arcuate nucleus glucokinase gene and protein expression to repeated intermediate insulin-induced hypoglycemia. (pp. 377-386). Neuroendocrinology.
Nedungadi, T. P., Briski, K. P. (2012). Site-specific effects of intracranial estradiol administration on recurrent insulin-induced hypoglycemia in ovariectomized female rats. (pp. 311-323). Neuroendocrinology.
Kale, A. Y., Paranjape, S. A., Briski, K. P. (2007). Site-specific habituation of insulin-induced hypoglycemic induction of Fos immunoreactivity in glucocorticoid receptor (GR)-immunopositive neurons in the male rat brain. (pp. 260-266). Experiemental Brain Research.
Briski, K. P., Vavaiya, K. V., Paranjape, S. A. (2007). Testicular regulation of neuronal glucose and monocarboxylate transporter gene expression profiles in CNS metabolic sensing sites during acute and recurrent insulin-induced hypoglycemia. (pp. 37-46). Journal of Molecular Neuroscience.
Patil, G. D., Briski, K. P. (2005). Transcriptional activation of nucleus tractus solitarius/area postrema catecholaminergic neurons by pharmacological inhibition of caudal hindbrain monocarboxylate transporter function. (pp. 96-102). Neuroendocrinology.
Kale, A. Y., Paranjape, S. A., Briski, K. P. (2007). Type II glucocorticoid receptor involvement in habituated insulin-induced hypoglycemic transcriptional activation of lateral hypothalamic orexin-A-immunopositive neurons. (pp. 309-313). Neuroscience Research.
Vavaiya, K. V., Paranjape, S. A., Briski, K. P. (2006). Vagal complex monocarboxylate transporter-2 expression during hypoglycemia. NeuroReport.
Vavaiya, K. V., Briski, K. P. (2008). Effects of caudal fourth ventricular lactate infusion on hypoglycemia-associated MCT2, GLUT3, GLUT4, GCK, and sulfonylurea receptor-1 gene expression in the ovariectomized female rat LHA and VMH: Impact of estradiol. (pp. 121-129). Journal of Molecular Neuroscience.
Vavaiya, K. V., Briski, K. P. (2008). Effects of caudal hindbrain lactate infusion on insulin-induced hypoglycemia and neuronal substrate transporter, glucokinase, and sulfonylurea receptor-1 gene expression in the ovariectomized female rat dorsal vagal complex: Impact of estradiol. (pp. 694-701). Journal of Neuroscience Research.
Singh, S., Briski, K. P. (2008). Hindbrain neuroglucopenia elicits site-specific transcriptional activation of glutamate decarboxylase immunopositive neurons in rat septopreoptic area. (pp. 113-120). Neuroendocrinology.
Vavaiya, K. V., Briski, K. P. (2007). Caudal hindbrain lactate administration alters glucokinase, SUR1, and neuronal substrate fuel transporter gene expression in the dorsal vagal complex, lateral hypothalamic area, and ventromedial nucleus hypothalamus of hypoglycemic male rats. (pp. 62-70). Brain Research.
Nedungadi, T. P., Briski, K. P. (2007). Effects of estradiol on acute and chronic insulin-induced hypoglycemia-associated patterns of arcuate neuropeptide Y, proopiomelanocortin, and cocaine- and amphetamine related-transcript gene expression in the ovariectomized female rat (pp. 270-276). Neuroendocrinology.

Research Grants

Briski, K. P. (Principal), "Estrogen Regulation of Hypothalamic Astrocyte Glycogen" (Funded), Sponsored By National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases, The University of Louisiana at Monroe, $1,647,428.. (September 19 2016 - July 31 2021).

Awards & Honors

August 2013 ULM Foundation Research Excellence Award.

Courses Taught

PHAR 4011Pharmacology I, 4 course(s)

PHAR 4012Pharmacology II, 1 course(s)

PHAR 4036Pharmacology Lab, 1 course(s)

PHAR 4065Problems, 3 course(s)

PHAR 5016STERILE PRODUCTS, 1 course(s)

PHAR 5022Adv Pharmacology Lab, 1 course(s)

PHAR 5051DIRECTED STUDY, 14 course(s)

PHAR 5099THESIS, 12 course(s)

PHAR 6051ADVANCED DIRECTED STUDY, 14 course(s)

PHAR 6099DISSERTATION, 47 course(s)

PHRD 4008PHARMACEUTICS I, 3 course(s)

PHRD 4012PATHOPHYSIOLOGY I, 12 course(s)

PHRD 4029PHARMACEUTICS II, 2 course(s)

PHRD 4035PATHOPHYSIOLOGY II, 5 course(s)

PHRD 4058Neurology & Psychiatry Module, 1 course(s)

PHRD 4072THERAPEUTICS II, 2 course(s)

PHRD 4074ENDOCRINE MODULE, 6 course(s)

PHRD 4083GASTRO NUTRITION & HEPTIC MOD, 2 course(s)

PHRD 5027BONE AND JOINT MODULE, 3 course(s)